Medigene’s lead candidate targeting the well-characterized cancer testis antigen NY-ESO-1 (New York esophageal squamous cell carcinoma 1) has shown to be highly expressed in a wide variety of cancer types. MDG1015 is a 3rd generation NY-ESO-1 targeted TCR-T Therapy – sensitive, specific TCR with a favorable safety profile, combined with our PD1-41BB costimulatory switch protein.
MDG1015 displayed increased T cell functionality as means of secretion of multiple cytokines when compared to the TCR without PD1-41BB switch protein “Naked TCR” (Figure 1).
Figure 1:
TCR-T functionality with MDG1015 vs. Naked TCR