The choice of the right epitope to be recognized by TCRs is critical for reducing off-target toxicities. Bioinformatic tools like Expitope enables the examination of the expression of newly identified epitopes in healthy tissue, especially in vital organs like the heart and brain, to avoid unspecific binding of TCRs leading to fatal damage to healthy tissue.
Target Screening Publications
Target Screening Abstracts
CIMT
Expitope 3.0 An Advanced in silico Webtool Empowered with Machine Learning for Enhanced pHLA Epitope Prediction and Safety Assessment Simone Thomas, Martin Sebastian Karg, Andrea Coluccio, Barbara Lösch, Dolores J Schendel, Dmitrij Frishman
TCR-based Therapies for Solid Tumors
Case Study Spotlight: Introducing Innovations at Each Step of TCR-T Therapy Development; Dolores Schendel
CAR-TCR Summit
Combined Molecular & Cellular Tools are Required to Assess Safety of TCR-T Immunotherapies; Tristan Holland
CIMT – Cancer Immunotherapy Annual Meeting 2013, Mainz
Wehner C., Ellinger C., Raffegerst S., Wilde S., Mosetter B., Schendel D.J., Milošević S., 2013. Isolation of antigen-specific CD8+ T lymphocytes and molecular characterization of antigenic epitopes. CIMT Mainz, Germany.