The choice of the right epitope to be recognized by TCRs is critical for reducing off-target toxicities. Bioinformatic tools like Expitope enables the examination of the expression of newly identified epitopes in healthy tissue, especially in vital organs like the heart and brain, to avoid unspecific binding of TCRs leading to fatal damage to healthy tissue.
Target Screening Publications
Target Screening Abstracts
A novel library of optimal affinity KRAS mutation-specific T cell receptors associated with multiple HLAs, in combination with a PD1-41BB armoring and enhancement costimulatory switch receptor
Dolores J Schendel, Giulia Longinotti, Mario Catarinella, Melanie Salvermoser, Julia Bittmann, Kirsty Crame, Kathrin Davari and Selwyn Ho
CIMT – Cancer Immunotherapy Annual Meeting 2013, Mainz
Wehner C., Ellinger C., Raffegerst S., Wilde S., Mosetter B., Schendel D.J., Milošević S., 2013. Isolation of antigen-specific CD8+ T lymphocytes and molecular characterization of antigenic epitopes. CIMT Mainz, Germany.