Target Screening

The choice of the right epitope to be recognized by TCRs is critical for reducing off-target toxicities. Bioinformatic tools like our proprietary EXPITope-M tools enable the examination of the expression of newly identified epitopes in healthy tissue, especially in vital organs like the heart and brain, to avoid unspecific binding of TCRs leading to fatal damage to healthy tissue.

Target Screening Publications

Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors
Anja Mösch, Silke Raffegerst, Manon Weis, Dolores J. Schendel and Dmitrij Frishman. Frontiers in Genetics Review published: 19 November 2019 doi: 10.3389/fgene.2019.01141
Assessment of cancer and virus antigens for cross-reactivity in human tissues
Jaravine, V., Raffegerst, S., Schendel, DJ., Frishman, D. Bioinformatics 2017 Jan 1;33(1):104-111. doi: 10.1093/bioinformatics/btw567.
Expitope: a web server for epitope expression
Haase, K., Raffegerst, S., Schendel, D., Frishman, D. Bioinformatics. 2015 Jun 1;31(11):1854-6. doi: 10.1093/bioinformatics/btv068.
Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay
Becker, C., Pohla, H., Frankenberger, B., Schüler, T., Assenmacher, M., Schendel, D.J. and Blankenstein, T. 2001. Nat Med.; 7 (10):1159–1162.

Target Screening Abstracts

CIMT

Expitope 3.0 An Advanced in silico Webtool Empowered with Machine Learning for Enhanced pHLA Epitope Prediction and Safety Assessment Simone Thomas, Martin Sebastian Karg, Andrea Coluccio, Barbara Lösch, Dolores J Schendel, Dmitrij Frishman

Presentation

Poster

TCR-based Therapies for Solid Tumors

Case Study Spotlight: Introducing Innovations at Each Step of TCR-T Therapy Development; Dolores Schendel

Presentation

CAR-TCR Summit

Combined Molecular & Cellular Tools are Required to Assess Safety of TCR-T Immunotherapies; Tristan Holland

Presentation

CIMT – Cancer Immunotherapy Annual Meeting 2013, Mainz

Wehner C., Ellinger C., Raffegerst S., Wilde S., Mosetter B., Schendel D.J., Milošević S., 2013. Isolation of antigen-specific CD8+ T lymphocytes and molecular characterization of antigenic epitopes. CIMT Mainz, Germany.

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