The choice of the right epitope to be recognized by TCRs is critical for reducing off-target toxicities. Bioinformatic tools like Expitope enables the examination of the expression of newly identified epitopes in healthy tissue, especially in vital organs like the heart and brain, to avoid unspecific binding of TCRs leading to fatal damage to healthy tissue.
Target Screening Publications
Target Screening Abstracts
CIMT – Cancer Immunotherapy Annual Meeting 2013, Mainz
Wehner C., Ellinger C., Raffegerst S., Wilde S., Mosetter B., Schendel D.J., Milošević S., 2013. Isolation of antigen-specific CD8+ T lymphocytes and molecular characterization of antigenic epitopes. CIMT Mainz, Germany.